Anthony Hopkins
Hannibal Lecter
Edward Norton
Will Graham
Ralph Fiennes
Francis Dolarhyde
Harvey Keitel
Jack Crawford
Emily Watson
Reba McClane
Mary-Louise Parker
Molly Graham
Philip Seymour Hoffman
Freddy Lounds
Anthony Heald
Dr. Frederick Chilton
Ken Leung
Lloyd Bowman
Frankie Faison
Barney Matthews
Tyler Patrick Jones
Josh Graham
Lalo Schifrin
Conductor
John Rubinstein
Dinner Guest
David Doty
Brenda Strong
Robert Curtis Brown
Mary Anne McGarry
Marc Abraham
Veronica De Laurentiis
Michael Cavanaugh
Forensic Dentist
Madison Mason
Police Commissioner
Bill Duke
Police Chief
Azura Skye
Bookseller
Stanley Anderson
Jimmy Price
Jeanine Jackson
Dr. Hassler
Ellen Burstyn
Grandma Dolarhyde (voice) (uncredited)
Mary Beth Hurt
Museum Curator (uncredited)
James Pickens Jr.
Male Zoo Doctor (uncredited)
Frank Whaley
Ralph Mandy (uncredited)
Tanya Newbould
Chromalux Secretary
Katie Rich
Woman Detective
Alex Berliner
Photographer
Tom Verica
Charles Leeds
Marguerite MacIntyre
Valerie Leeds
Elizabeth Dennehy
Beverly
William Lucking
Byron Metcalf
Joseph Simmons
Janitor
Mark Moses
Father in Video
Lisa Haley
Musician
Lisa Thornhill
Mrs. Sherman