Bộ phim theo chân những kẻ sống ngoài vòng pháp luật, cao bồi và những người di cư khi họ phải chiến đấu giữa phong cảnh sa mạc khắc nghiệt vùng viễn tây.
Tim Blake Nelson
Buster Scruggs (segment "The Ballad of Buster Scruggs")
James Franco
Cowboy (segment "Near Algodones")
Zoe Kazan
Alice Longabaugh (segment "The Gal Who Got Rattled")
Liam Neeson
Impresario (segment "Meal Ticket")
Tom Waits
Prospector (segment "All Gold Canyon")
Tyne Daly
Mrs. Betjeman (segment "The Mortal Remains")
Brendan Gleeson
Clarence (segment "The Mortal Remains")
Jonjo O'Neill
Thigpen (segment "The Mortal Remains")
Saul Rubinek
René (segment "The Mortal Remains")
Chelcie Ross
Trapper (segment "The Mortal Remains")
Bill Heck
Billy Knapp (segment "The Gal Who Got Rattled")
Harry Melling
Harrison (segment "Meal Ticket")
Willie Watson
The Kid (segment "The Ballad of Buster Scruggs")
E.E. Bell
Saloon Piano Player (segment "The Ballad of Buster Scruggs")
David Krumholtz
Frenchman in Saloon (segment "The Ballad of Buster Scruggs")
Tom Proctor
Cantina Bad Man (segment "The Ballad of Buster Scruggs")
Clancy Brown
Curly Joe (segment "The Ballad of Buster Scruggs")
Stephen Root
Teller (segment "Near Algodones")
Ralph Ineson
The Man In Black (segment "Near Algodones")
Jesse Luken
Drover (segment "Near Algodones")
Sam Dillon
Young Man (segment "All Gold Canyon")
Grainger Hines
Mr. Arthur (segment "The Gal Who Got Rattled")
Jefferson Mays
Gilbert Longabaugh (segment "The Gal Who Got Rattled")
Ethan Dubin
Matt (segment "The Gal Who Got Rattled")
Matthew Willig
Hard Man #3 (segment "The Ballad of Buster Scruggs")
Paul Rae
Impressario (segment "Meal Ticket")
Tim DeZarn
Angry Man (segment "The Ballad of Buster Scruggs")
Martin Palmer
Blubberer (segment "Near Algodones")
Danny McCarthy
Ike (segment "The Ballad of Buster Scruggs")
Billy Lockwood
Father (segment "The Gal Who Got Rattled)
Jackamoe Buzzell
Another Man (segment "The Gal Who Got Rattled)
J. Nathan Simmons
Gallows Watcher (segment "The Ballad of Buster Scruggs")
Katy Bodenhamer
Milkmaid (segment "The Gal Who Got Rattled)
Jiji Hise
The Bawd (segment "Meal Ticket")
Austin Rising
The Bailiff (segment "The Ballad of Buster Scruggs")
Stephen R. Estler
Gambler (segment "The Ballad of Buster Scruggs")
Grace LeSueur
Pretty Girl at Gallows (segment "The Ballad of Buster Scruggs")