Bộ phim xoay quanh một nhóm phi hành gia trên tàu vũ trụ U.S.S. Enterprise. Trong chuyến phiêu lưu đầy mạo hiểm, họ phải tìm cách ngăn chặn Thuyền trưởng Nero, thuộc tộc người Romulan, kẻ đang có âm mưu tàn sát toàn nhân loại.
Chris Pine
James T. Kirk
Zachary Quinto
Spock
Leonard Nimoy
Spock Prime
Eric Bana
Nero
Bruce Greenwood
Christopher Pike
Karl Urban
Leonard 'Bones' McCoy
Zoe Saldana
Nyota Uhura
Simon Pegg
Montgomery Scott
John Cho
Hikaru Sulu
Anton Yelchin
Pavel Chekov
Ben Cross
Sarek
Winona Ryder
Amanda Grayson
Chris Hemsworth
George Kirk
Jennifer Morrison
Winona Kirk
Rachel Nichols
Galia
Faran Tahir
Captain Robau
Clifton Collins Jr.
Ayel
Greg Ellis
Chief Engineer Olsen
Scottie Thompson
Nero's Wife
Paul McGillion
Barracks Officer
Lucia Rijker
Romulan Communications Officer
Jimmy Bennett
Young James T. Kirk
Greg Grunberg
Stepdad (voice)
Lisa Vidal
Jacob Kogan
Young Spock
Tyler Perry
Admiral Richard Barnett
Amanda Foreman
Hannity
Diora Baird
The Wrong Orion
Sufe Bradshaw
Cadet Alien
Tony Elias
Officer Pitts
Sean Gerace
Tactical Officer
Randy Pausch
Kelvin Crew Member
Tim Griffin
Kelvin Engineer
Freda Foh Shen
Kelvin Helmsman
Kasia Kowalczyk
Kelvin Alien
Jason Brooks
Romulan Helmsman
Sonita Henry
Kelvin Doctor
Kelvin Yu
Medical Technician
Marta Martin
Tavarus Conley
Jeff Castle
Billy Brown
Med Evac Pilot
Spencer Daniels
Johnny
Jeremy Fitzgerald
Iowa Cop
Zoe Chernov
Vulcan Student
Max Chernov
Lorenzo James Henrie
Vulcan Bully
Colby Paul
Cody Klop
Akiva Goldsman
Vulcan Council Member
Anna Katarina
Douglas Tait
Long Face Bar Alien
Tony Guma
Lew the Bartender
Gerald W. Abrams
Barfly
James McGrath
Jason Matthew Smith
Burly Cadet
Marcus Young
Bob Clendenin
Shipyard Worker
Reggie Lee
Test Administrator
Jeffrey Byron
Jonathan Dixon
Simulator Tactical Officer
Ben Binswagner
Admiral James Komack
Margot Farley
College Council Stenographer
Alex Nevil
Shuttle Officer
Kimberly Arland
Jeff Chase
Charles Haugk
Enterprise Crew Member
Nana Hill
Michael Saglimbeni
John Blackman
Jack Millard
Shaela Luter
Sabrina Morris
Michelle Parylak
Oz Perkins
Enterprise Communiations Officer
Michael Berry Jr.
Romulan Tactical Officer
Matthew Beisner
Romulan Crew Member
Neville Page
Jesper Inglis
Marlene Forte
Transport Chief
Leonard O. Turner
Vulcan Elder
Mark Bramhall
Ronald F. Hoiseck
Irene Roseen
Jeff O'Haco
Deep Roy
Keenser
Majel Barrett
Starfleet Computer (voice)
Rico E. Anderson
Council Member - Captain Kelley Bogel (uncredited)
Richard Arnold
Romulan Science Tech (uncredited)
Tad Atkinson
Amphibian Prisoner (uncredited)
Leslie Augustine
Doctor (uncredited)
Johnny Baca
Starfleet Cadet (uncredited)
Sala Baker
Drill Tower Romulan (uncredited)
Leo Baligaya
Corey Becker
Jessica Boss
Bridgeport Cadet (uncredited)
Neil S. Bulk
James Cawley
Enterprise Crewmember (uncredited)
Brad Champagne
Zachary Culbertson
Calvin Dean
Security Officer Daniels (uncredited)
Christopher Doohan
Starfleet Officer (uncredited)
Claire Doré
Enterprise Crew Member (uncredited)
Mark Casimir Dyniewicz
Klingon Prisoner - Nero's Flashback (uncredited)
Etienne Eckert
Vulcan Federation Officer (uncredited)
Ken Edling
Aliza Finley
Hurried Cadet with Clipboard (uncredited)
Ian Fisher
Shipyard Worker (uncredited)
Mathew Thomas Foss
Massi Furlan
Missile Launcher (uncredited)
Victor Garber
Klingon Interrogator (scenes deleted) (uncredited)
Tommy Germanovich Jr.
FourSquare (uncredited)
Mary Grace
Shipyard Bar Patron (uncredited)
Wyatt Gray
Joshua Greene
Child Running in Snow (uncredited)
Nancy Guerriero
Crew Member (uncredited)
Justin Rodgers Hall
Starfleet Security Officer (uncredited)
Jeffery Hauser
Kelvin Crew Member (uncredited)
Brad William Henke
Uncle Frank (uncredited) (unconfirmed)
Elizabeth Ingalls
Enterprise Nurse (uncredited)
Christopher Karl Johnson
Jolene Kay
Sarah Klaren
Makiko Konishi
Bryan Lee
Daniel D. Lee
Starfleet Commander (uncredited)
Anne Leighton
Steve Luna
Lieutenant Star Fleet Command (uncredited)
Aaron Lynch
Flight Operational Air Safety Conductor (uncredited)
Justin Malachi
Nav Mann
Romulan Crew Member Placing Bomb (uncredited)
Paul Marshall
Bar Patron (uncredited)
Owen Martin
Alien Cadet / Enterprise Crew (uncredited)
Taylor McCluskey
Kelvin Alien (uncredited)
Matthew McGregor
Caitlin McKenna-Wilkinson
Kelvin Computer (uncredited)
Patrizia Milano
Councilwoman (uncredited)
Kevin Moser
Enterprise Crewman (uncredited)
Jonathan W.D. Newkerk
Westley Nguyen
Jim Nieb
Sal (uncredited)
Andres Perez-Molina
Romulan Crew Member (uncredited)
Mark Phelan
Romulan (uncredited)
Damion Poitier
Drill Hanson #1 (uncredited)
Rahvaunia
Academy Teacher (uncredited)
Bertrand Roberson Jr.
Shuttle Cadet (uncredited)
Deborah Rombaut
Leonard Jonathan Ruebe
Ramona Seymour
William Morgan Sheppard
Vulcan Science Minister (uncredited)
Katie Soo
Ronnie Steadman
Shuttle Pilot (uncredited)
Joseph Stephens Jr.
Cadet Officer (uncredited)
Joseph Steven
Romulan Engineer (uncredited)
T.J. Storm
Klingon Agitator (uncredited)
Paul Townsend
Scott Trimble
Klingon Prison Guard (uncredited)
Errik Tustenuggee
Federation Captain Cartwright (uncredited)
Ravi Valleti
Cadet at Trial (uncredited)
Jason Vaughn
A.J. Verel
Brian Waller
Vulcan Council Member (uncredited)
Steve Wharton
Star Fleet Cadet (uncredited)
Wil Wheaton
Romulan (voice) (uncredited)
Brianna Womick
Lynnanne Zager
Enterprise Computer (voice) (uncredited)
Pavel Lychnikoff
Romulan Officer
Darlena Tejeiro
Flight Officer