Alice tỉnh dậy tại thành phố Raccoon- nơi mà cư dân ở đây đã bị biến thành zombie và quái vật. Với sự giúp đỡ của Jill Valentine, Carlos Olivera, Alice phải tìm một cách ra khỏi thành phố này trước khi nó bị phá hủy bởi tên lửa hạt nhân.
Milla Jovovich
Alice
Sienna Guillory
Jill Valentine
Oded Fehr
Carlos Olivera
Thomas Kretschmann
Major Cain
Sophie Vavasseur
Angie Ashford
Razaaq Adoti
Sgt. Peyton Wells
Jared Harris
Dr. Ashford
Mike Epps
L.J.
Sandrine Holt
Terri Morales
Matthew G. Taylor
Nemesis
Zack Ward
Nicholai Ginovaeff
Iain Glen
Dr. Isaacs
Dave Nichols
Captain Henderson
Stefan Hayes
Yuri Loginova
Geoffrey Pounsett
Mackenzie
Shaun Austin-Olsen
Priest
Geny Walters
Mrs. Priest
Megan Fahlenbock
Marla Mapes
Robert Morelli
Director
Aaron Abrams
Assistant
Chris Benson
Lance Halloran
Martin Martinuzzi
Overworked Detective
Brad Borbridge
Overworked Sergeant
Frank Chiesurin
Sniper
Ron Benjamin
Bum
Kevin Hare
Home Owner / Scientist
Heather Dick
Older Woman
Alex Courey
Suit #1
John Detoro
Suit #2
Billy Khoury
Suit #3
Sava Drayton
Suit #4
Nicole Ann St. Hill
Undead Gaudy Hooker
Ricardo Betancourt
Burly Cop #1
Ted Ludzik
Burly Cop #2
Michelle Latimer
Tech #1
Catherine Burdon
Tech #2
Rebecca Sims
Undead Little Girl
Christopher Weedon
Undead Little Boy #1
Billy Parrott
Security Guard
Derek Aasland
Featured Graveyard Undead 1 (as Derek Asland) / Featured "Surplus" Undead #3
Richard Harte
Featured Graveyard Undead 2 / Featured Rooftop Undead #2
Simon Girard
Chopper Pilot #1
Dean Copkov
Chopper Pilot #2
Jeff White
Chopper Pilot #4
Tim Burd
Refugee #1
Natalie Charles
Refugee #2
Pierre Henry
Screaming Soldier
Jim Codrington
Lieutenant
Deborah Valente
Tech
Malcolm Fiddick
Reflection Undead
Malcolm Xerxes
Featured City Hall Undead #1
Michy Gustavia
Featured City Hall Undead #2
Shane Mackinnon
Featured City Hall Undead #3
Ed Fielding
Featured City Hall Undead #4
Stephen R. Hart
Featured City Hall Undead #5
Sandi Stahlbrand
Reporter #1
Christopher Marren
Guard
Tom Gerhardt
Zombie Dad
Amber Marshall
Daughter
Venice Grant
Undead Stripper #1
Ana Danilina
Undead Stripper #2
Ingrid Johansson
Featured IV Woman Undead
Jeffrey Weedon
Undead Little Boy #2
Melanie Tonello
Featured Undead Kid #1
Annabel Chu
Featured Undead Kid #2
Joey Jefferson
Featured Undead Kid #3
Heather Braaten
Featured Rooftop Undead #1
Joey Beck
Featured Rooftop Undead #3
Eric Morgan
Featured Undead City Walker #1
Gene Pyrz
Featured Undead City Walker #2
Torquil Colbo
Featured Undead City Walker #3
Joan Moore
Featured Undead City Walker #4
Peter C. Wylde
Featured Undead City Walker #5
Garry Geddes
Featured Undead City Walker #6
Dionne Renee
Featured Undead City Walker #7
Janessa Crimi
Featured Undead Kid #4
Dan Ellery
Featured Graveyard Undead 1
Sharon Moore
Featured "Surplus" Undead #2
Jo Chim
Network Anchor #1
Bobby Prochaska
Network Anchor #2
Jazz Mann
Reporter #2
Larissa Gomes
Reporter #3
Gregory White
Lab Technician
Roman Podhora
Leader Umbrella Guard
Brian King
Umbrella Gate Guard
Rob Hall
Featured School Undead
John Migliore
Zombie (uncredited)
Eric Mabius
Matt Addison (archive footage)
Liz May Brice
(archive footage)
Pasquale Aleardi
Michelle Rodriguez