Laura Linney
Dr. Karen Ross
Dylan Walsh
Dr. Peter Elliot
Ernie Hudson
Captain Munro Kelly
Tim Curry
Herkermer Homolka
Grant Heslov
Richard
Adewale Akinnuoye-Agbaje
Kahega
Joe Don Baker
R.B. Travis
Lorene Noh
Amy
Mary Ellen Trainor
Moira
Misty Rosas
Amy the Gorilla
Stuart Pankin
Boyd
Carolyn Seymour
Eleanor Romy
Romy Rosemont
Assistant
James Karen
College President / Elliot's Boss
Bill Pugin
William
Lawrence T. Wrentz
Prof. Arliss Wender
John Hawkes
Bob Driscoll
Bruce Campbell
Charles Travis
Jimmy Buffett
727 Pilot
Thom Barry
Samahani
Karara Muhoro
Roadblock Soldier
Kevin Grevioux
Roadblock Officer
Taylor Nichols
Jeffrey Weems
Joel Weiss
TraviCom Operator
Robert Almodovar
Rudy, TraviCom Security
Peter Jason
Mr. Janus
Delroy Lindo
Captain Wanta (uncredited)
Joe Pantoliano
Eddie Ventro (uncredited)
Kathleen Connors
Sally
James Paradise
Transport Worker #1
William John Murphy
Transport Worker #2
Ayo Adejugbe
African Airport Guard
Darnell Suttles
Hospital Interrogator
Michael Chinyamurindi
Claude from Mombasa
Willie Amakye
Lead Porter
Malang
Porter
Jay Speed Forney
Shelton Mack
David Mungai
Anthony Mutune
Sylvester Mwangi
Les Robinson
Nelson Shalita
E.J. Callahan
DC-3 Pilot
Guy Toley
DC-3 Co-Pilot
Jackson Gitonga
Mizumu Tribesman
Andrew Kamuyu
Fidel Bateke
Witch Doctor
Shayna Fox
Amy (voice)
David Anthony
Gorilla
Brian La Rosa
John Munro Cameron
Gorilla (as John Cameron)
John Alexander Lowe
Jay Caputo
Garon Michael
Peter Elliott
David St. Pierre
Eldon Jackson
Philip Tan
Nicholas Kadi
Christopher 'Critter' Antonucci